Synthesis of some new steroidal [16α, 17α-d]-isoxazolines

被引：17

作者：

Chowdhury, P ^{[1
]}

Das, AM ^{[1
]}

Goswami, P ^{[1
]}

机构：

[1] Reg Res Lab, Nat Prod Chem Div, Jorhat 785006, Assam, India

来源：

STEROIDS | 2005年 / 70卷 / 08期

关键词：

16-dehydropregnenolone acetate; 21-chloro-20-oxopregnane; cycloaddition reactions; steroidal[16,17-d; isoxazolines; topical anti-inflammatory agents;

D O I：

10.1016/j.steroids.2005.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regioselective synthesis of novel steroidal anti-inflammatory ante drug analogues. viz.. [16 alpha,17 alpha-d]-isoxazolines 1(a-h) and 2(a-h) prepared in a single step in good yield by the reaction of 16-dehydropregnenol one acetate ( 16-DPA) I or related 21 -chloro-20-oxopregnane 2 with various aldoximes (a-h) in presence of chlorarnine-T in refluxing ethanol. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：494 / 498

页数：5

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