The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults

被引：25

作者：

Cunningham, Jason ^{[1
]}

Basu, Kaninika ^{[1
,2
]}

Tavendale, Roger ^{[3
]}

Palmer, Colin N. A. ^{[3
]}

Smith, Helen ^{[4
]}

Mukhopadhyay, Somnath ^{[1
,2
]}

机构：

[1] Royal Alexandra Hosp Children, Brighton & Sussex Med Sch, Brighton BN2 5BE, E Sussex, England

[2] Univ Dundee, Ninewells Hosp & Med Sch, Tayside Inst Child Hlth, Dundee DD1 9SY, Scotland

[3] Univ Dundee, Ninewells Hosp & Med Sch, Biomed Res Inst, Populat Pharmacogenet Grp, Dundee DD1 9SY, Scotland

[4] Brighton & Sussex Med Sch, Div Publ Hlth & Primary Care, Brighton, E Sussex, England

来源：

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | 2011年 / 106卷 / 05期

关键词：

D O I：

10.1016/j.anai.2011.01.030

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Asthma exacerbations are the commonest cause of medical admissions in childhood. These have a significant effect on quality of life and are a major financial burden on worldwide healthcare services. A range of gene environment interactions may influence the course and severity of asthma in children and their response to medication. The Chitinase 3-like 1 (CHI3L1)-131C>G genotype (rs4950928) is associated with increased asthma susceptibility and severity in adults. Objectives: To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma. Methods: A cross-sectional survey was undertaken using medical records and direct interviews of 1,071 children and young adults with asthma, aged 3 to 22 years, from Scotland. Saliva samples were collected for genotyping. Binary logistic regression was used to calculate odds ratios (ORs) and P-values for measures of asthma exacerbations. Results: The minor -131G allele confers protection against asthma-related hospital admissions (OR = 0.62; 95% CI 0.41-0.92; P = .018) in children and young adults with asthma. Conclusions: Our study shows that rs4950928 is significantly associated with hospital admissions in children and young adults; screening for rs4950928 may predict asthma-related hospital admissions, and through individually defined treatment management plans, potentially reduce health care costs. Ann Allergy Asthma Immunol. 2011;106:381-386.

引用

页码：381 / 386

页数：6

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