Recent Developments in Solid-Phase Strategies towards Synthetic, Sequence-Defined Macromolecules

被引：46

作者：

Hill, Stephen A. ^{[1
]}

Gerke, Christoph ^{[1
]}

Hartmann, Laura ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Organ Chem & Macromol Chem, Univ Str 1, D-40225 Dusseldorf, Germany

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2018年 / 13卷 / 23期

关键词：

poly(amidoamines); polymerization; sequence-controlled polymers; sequence-defined macromolecules; solid phase; ITERATIVE EXPONENTIAL-GROWTH; ORTHOGONAL SYNTHESIS; SCALABLE SYNTHESIS; PEPTIDE SYNTHESIS; PEPTOID POLYMERS; OLIGOMERS; INFORMATION; GLYCOMACROMOLECULES; PHOSPHORAMIDITE; POLYMERIZATION;

D O I：

10.1002/asia.201801171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sequence-control in synthetic polymers is an important contemporary research area because it provides the opportunity to create completely novel materials for structure-function studies. This is especially relevant for biomimetic polymers, bioactive and information security materials. The level of control is strongly dependent and inherent upon the polymerization technique utilized. Today, the most established method yielding monodispersity and monomer sequence-definition is solid-phase synthesis. This Focus Review highlights recent advances in solid-phase strategies to access synthetic, sequence-defined macromolecules. Alternatives strategies towards sequence-defined macromolecules are also briefly summarized.

引用

页码：3611 / 3622

页数：12

共 92 条

[1] Synthesis of Non-Natural Sequence-Encoded Polymers Using Phosphoramidite Chemistry [J].