Characterization of the Karyotype in Patients with Multiple Myeloma by the Combination of Karyotype Analysis, FISH and CGH

被引：0

作者：

Busert, Barbara ^{[1
]}

Schwanitz, Gesa ^{[1
]}

Schubert, Regine ^{[1
]}

Gamerdinger, Ulrike ^{[2
]}

Schmidt-Wolf, Ingo G. H. ^{[3
]}

机构：

[1] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany

[2] Univ Giessen, Inst Pathol, D-35390 Giessen, Germany

[3] Univ Bonn, Dept Internal Med 3, D-5300 Bonn, Germany

来源：

INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2010年 / 10卷 / 04期

关键词：

Multiple Myeloma; Phenotype-Karyotype Correlation; Plasma Cells; MACS/DOP-PCR; FISH-CGH; IN-SITU HYBRIDIZATION; COMPARATIVE GENOMIC HYBRIDIZATION; ABERRATIONS; ABNORMALITIES; 11Q;

D O I：

10.1080/09723757.2010.11886108

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cytogenetic and molecular cytogenetic investigations from bone marrow samples were performed in 83 patients with multiple myeloma. Karyotype analyses were made after cultivation with and without growth factors. The polyploidy level ranged from 3n to 6n. For each patient the composite karyotype was delineated. The number of abnormalities per aberrant cell was in a range from 1 to 17 ((x) over bar =3,7). The comparison of CGH and FISH results showed an accordance of 92%. In total, 57% of cells showed chromosomal aberrations.

引用

页码：217 / 222

页数：6

共 17 条

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