Optical-Property-Enhancing Novel Near-Infrared Active Niosome Nanoformulation for Deep-Tissue Bioimaging

被引：14

作者：

Bishnoi, Suman ^{[1
]}

Rehman, Sheeba ^{[1
]}

Dutta, Surjendu Bikash ^{[1
]}

De, Soumya Kanti ^{[2
]}

Chakraborty, Anjan ^{[2
]}

Nayak, Debasis ^{[1
]}

Gupta, Sharad ^{[1
,3
]}

机构：

[1] Indian Inst Technol Indore, Dept Biosci & Biomed Engn, Indore 453552, Madhya Pradesh, India

[2] Indian Inst Technol Indore, Dept Chem, Indore 453552, Madhya Pradesh, India

[3] Jawaharlal Nehru Univ, Sch Biotechnol, New Delhi 110067, India

来源：

ACS OMEGA | 2021年 / 6卷 / 35期

关键词：

FLUORESCENCE QUANTUM YIELDS; INDOCYANINE GREEN; IN-VITRO; DELIVERY; NANOPARTICLES; CHOLESTEROL; ABSORPTION; SYSTEMS; IMAGE;

D O I：

10.1021/acsomega.1c02632

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Indocyanine green (ICG) is a clinically approved near-infrared (NIR) contrast agent used in medical diagnosis. However, ICG has not been used to its fullest for biomedical imaging applications due to its low fluorescence quantum yield, aqueous instability, concentration-dependent aggregation, and photo and thermal degradations, leading to quenching of its fluorescence emission. In the present study, a nanosized niosomal formulation, ICGNiosomes (ICGNios), is fabricated to encapsulate and protect ICG from degradation. Interestingly, compared to free ICG, the ICGNios exhibited higher fluorescence quantum yield and fluorescence emission with a bathochromic shift. Also, ICGNios nanoparticles are biocompatible, biodegradable, and readily uptaken by the cells. Furthermore, ICGNios show more enhanced fluorescence intensity through similar to 1 cm thick chicken breast tissue compared to free ICG, which showed minimal emission through the same thickness of tissue. Our results suggest that ICGNios could offer a promising platform for deep-tissue NIR in vivo imaging to visualize inaccessible tissue microstructures for disease diagnosis and therapeutics.

引用

页码：22616 / 22624

页数：9

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