Expression cloning of a full-length cDNA encoding delta opioid receptor from mouse thymocytes

被引：19

作者：

Sedqi, M ^{[1
]}

Roy, S ^{[1
]}

Ramakrishnan, S ^{[1
]}

Loh, HH ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT SURG,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1996年 / 65卷 / 02期

关键词：

delta opioid receptor; thymocytes; immune cells;

D O I：

10.1016/0165-5728(96)00028-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A delta opioid receptor complementary DNA (cDNA) was cloned by expression of cDNA library from activated thymocytes in Cos 7 cells. The deduced amino acid sequence of this receptor was similar to that described in the brain. As analyzed by southern blot hybridization, the delta opioid receptor transcripts are constitutively expressed in unactivated thymocytes. In addition, neither kappa nor mu opioid receptor transcripts were detected in thymocytes, suggesting tissue-specific opioid receptor gene expression in the immune system. The studies represent the first report of a full-length opioid receptor in the immune system.

引用

页码：167 / 170

页数：4

共 19 条

[1]

Apte R N, 1989, Int Immunol, V1, P465, DOI 10.1093/intimm/1.5.465

[2]

CHEN Y, 1993, MOL PHARMACOL, V44, P8

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