An in vivo and in vitro potential of Indian ayurvedic herbal formulation Triphala on experimental gouty arthritis in mice

被引：42

作者：

Sabina, E. P. ^{[1
]}

Rasool, M. ^{[1
]}

机构：

[1] VIT Univ, Fac Biosci, Sch Bioengn & Biosci, Vellore 632014, Tamil Nadu, India

来源：

VASCULAR PHARMACOLOGY | 2008年 / 48卷 / 01期

关键词：

Triphala; gouty arthritis; lysosomal enzymes; tumour necrosis factor-alpha; lipid peroxidation;

D O I：

10.1016/j.vph.2007.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study, we have investigated the efficacy of Indian ayurvedic herbal formulation Triphala on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, Indomethacin. The anti-arthritic effect of Triphala was evaluated by measuring changes in the paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidant status and inflammatory mediator TNF-alpha in control and monosodium. urate crystal-induced mice. The levels of beta-glucuronidase and lactate dehydrogenase were also measured in monosodium urate crystal-incubated polymorphonuclear leucocytes (PMNL). Triphala treatment (1 gm/kg/b.w. orally) significantly inhibited the paw volume and the levels of lysosomal enzymes, lipid peroxidation and inflammatory mediator tumour necrosis factor-alpha; however the anti-oxidant status was found to be increased in plasma, liver and spleen of monosodium urate crystal-induced mice when compared to control mice. In addition, beta-glucuronidase and lactate dehydrogenase level were reduced in Triphala (100 mu g/ml) treated monosodium urate crystal-incubated polymorphonuclear leucocytes. In conclusion, the results obtained clearly indicated that Triphala exerted a strong anti-inflammatory effect against gouty arthritis. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：14 / 20

页数：7

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