Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats

被引：29
作者：
Rahmani, Ghazal [1 ]
Farajdokht, Fereshteh [1 ]
Mohaddes, Gisou [1 ]
Babri, Shirin [1 ]
Ebrahimi, Vida [2 ]
Ebrahimi, Hadi [1 ]
机构：
[1] Tabriz Univ Med Sci NSRC, Neurosci Res Ctr, Golgasht St,Azadi Ave, Tabriz 5166614756, Iran
[2] Tabriz Univ Med Sci, Dept Pharmaceut Biotechnol, Fac Pharm, Tabriz, Iran
来源：
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2020年 / 126卷 / 02期
关键词：
Diabetes; garlic; anxiety; depression; oxidative stress; ANTIDEPRESSANT-LIKE ACTIVITY; EXTRACT; ADULTS; PHYTOCHEMICALS; EXERCISE; MELLITUS; PLANTS; HEART; ONION; MICE;
D O I：
10.1080/13813455.2018.1494746
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study investigated the effects of garlic on anxiety- and depression-related behaviors and brain oxidative markers in streptozotocin (STZ)-induced diabetes in rats. Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8/group): control, diabetic + saline, diabetic + garlic, diabetic + imipramine, and diabetic + diazepam groups. Animals received garlic homogenate (0.1, 0.25, and 0.5 g/kg) for 10 days. At the end of the treatments, anxiety- and depressive-related behaviors were evaluated by elevated plus maze (EPM) and forced swimming test (FST), respectively. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and malondialdehyde (MDA) levels were measured in the brain. Diabetic + garlic (0.5 g/kg) group showed lower anxiety- and- depressive-like behaviors as compared to the diabetic rats. Furthermore, garlic treatment (0.5 g/kg) attenuated MDA levels and enhanced SOD and GPx activities in the brain. Our findings indicate that garlic alleviates anxiety- and depression-related behaviors in the diabetic rats possibly by attenuation of brain oxidative stress.
引用
收藏
页码：95 / 100
页数：6
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