1,2,4-TRIAZOLES AS INTERMEDIATES FOR THE SYNTHESIS OF HYBRID MOLECULES

被引：0
作者：
Serban, Georgeta [1 ]
机构：
[1] Univ Oradea, Fac Med & Pharm, Dept Pharmaceut Chem, 29 Nicolae Jiga, Oradea 410028, Romania
来源：
FARMACIA | 2016年 / 64卷 / 04期
关键词：
1,2,4-triazoles; hybrid molecules; isothiocyanates; intramolecular cyclization; BIOLOGICAL-ACTIVITY; DOCKING; TRIAZOLES; AGENTS; DESIGN;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This paper aim was to present some new heterocyclic compounds from the class of 1,2,4-triazole-3-thione which have been synthesized by intramolecular cyclization of the corresponding thiosemicarbazides with ammonia. 4-R-1-cyanoacetylthiosemicarbazides were obtained by nucleophilic addition of cyanoacetic acid hydrazide to different isothiocyanates. The structures of the newly synthesized compounds were elucidated by spectral data and elemental analysis..
引用
收藏
页码：549 / 552
页数：4
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