1,2,4-TRIAZOLES AS INTERMEDIATES FOR THE SYNTHESIS OF HYBRID MOLECULES

被引：0

作者：

Serban, Georgeta ^{[1
]}

机构：

[1] Univ Oradea, Fac Med & Pharm, Dept Pharmaceut Chem, 29 Nicolae Jiga, Oradea 410028, Romania

来源：

FARMACIA | 2016年 / 64卷 / 04期

关键词：

1,2,4-triazoles; hybrid molecules; isothiocyanates; intramolecular cyclization; BIOLOGICAL-ACTIVITY; DOCKING; TRIAZOLES; AGENTS; DESIGN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper aim was to present some new heterocyclic compounds from the class of 1,2,4-triazole-3-thione which have been synthesized by intramolecular cyclization of the corresponding thiosemicarbazides with ammonia. 4-R-1-cyanoacetylthiosemicarbazides were obtained by nucleophilic addition of cyanoacetic acid hydrazide to different isothiocyanates. The structures of the newly synthesized compounds were elucidated by spectral data and elemental analysis..

引用

页码：549 / 552

页数：4

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