MRI-guided fluorescence tomography of PPIX in the breast: A case study

被引：1
作者：
Davis, Scott C. [1 ]
Mastanduno, Michael A. [1 ]
Pogue, Brian W. [1 ]
Paulsen, Keith D. [1 ]
机构：
[1] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA
来源：
MULTIMODAL BIOMEDICAL IMAGING VI | 2011年 / 7892卷
关键词：
Fluorescence tomography; MRI; multi-modal imaging; protoporphyrin IX; spectroscopy; breast imaging; OPTICAL TOMOGRAPHY; IN-VIVO; ORAL APPLICATION; CANCER; INFORMATION; PHANTOMS; SINGLE; TUMORS;
D O I：
10.1117/12.875775
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A case study to demonstrate fluorescence tomography of endogenous protoporphyrin IX (PPIX) in breast cancer is presented. An MRI-coupled fluorescence tomography system with spectrometer detectors was used to acquire excitation and emission data through the breast of a human subject undergoing chemotherapy for breast cancer. Volumetric images of PPIX fluorescence showed elevated levels of fluorescence activity in the fibro-glandular tissue as compared to the adipose tissue. Fluorescence levels in the tumor were higher than in the adipose tissue but lower than the fibro-glandular tissue.
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页数：5
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