Multicomponent reactions of carbonyl compounds and derivatives of cyanoacetic acid: Synthesis of carbo- and heterocycles

We present herein a review of multicomponent reactions of carbonyl compounds with derivatives of cyanoacetic acid, and denote their differences from other well-known multicomponent reactions. Although this class of multicomponent reactions is widely used in organic chemistry for the synthesis of carbo- and heterocycles, it has not yet been reviewed in a separate publication. This review includes available information on the synthesis of carbocycles (substituted cyclopropanes, spiro-conjugated cyclopropanes, five-and six-membered carbocycles), five-membered heterocycles (furans, thiophenes, pyrroles, thiazoles, and others), and six-membered heterocycles (pyrans, thiopyrans, and pyridines) using the multicomponent reaction of carbonyl compounds with derivatives of cyanoacetic acid.