Efficient synthesis of highly substituted pyrrolin-4-ones via PIFA-mediated cyclization reactions of enaminones

被引：104
作者：
Huang, Jie
Liang, Yongjiu
Pan, Wei
Yang, Yang
Dong, Dewen [1 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 26期
关键词：
NITROGEN-BRIDGED HETEROCYCLES; PEPTIDE HYBRID LIGAND; MHC PROTEIN HLA-DR1; ONE-POT SYNTHESIS; S BOND FORMATION; OLEFIN AMIDOHYDROXYLATION; POLYVALENT IODINE; CRYSTAL-STRUCTURE; FORMAL SYNTHESIS; RING-SYSTEMS;
D O I：
10.1021/ol702362n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient and efficient synthesis of highly substituted pyrrolin-4-ones is developed via the PIFA-mediated cyclization reactions of readily available enaminones, and a mechanism involving sequential cleavage of N-C bond, formation of new N-C bond, intramolecular addition reaction, and benzilic acid type rearrangement is proposed.
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收藏
页码：5345 / 5348
页数：4
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