Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery System to Improve the Antitumor Effect of Paclitaxel

被引：10

作者：

Xu, Xiaoyan ^{[1
]}

Wu, Chao ^{[1
]}

Bai, Andi ^{[1
]}

Liu, Xuan ^{[1
]}

Lv, Huiling ^{[1
]}

Liu, Ying ^{[1
]}

机构：

[1] Jinzhou Med Univ, Pharm Sch, 40 Songpo Rd, Jinzhou 121000, Liaoning, Peoples R China

来源：

JOURNAL OF NANOMATERIALS | 2017年 / 2017卷

基金：

中国国家自然科学基金;

关键词：

ANTIBODY FRAGMENT; BIODISTRIBUTION; ACID; NANOCARRIERS; EXPRESSION; MICELLES; EFFICACY; RELEASE;

D O I：

10.1155/2017/2069685

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized MSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system for liver cancer chemotherapy.

引用

页数：13

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