Folate-Functionalized Mesoporous Silica Nanoparticles as a Liver Tumor-Targeted Drug Delivery System to Improve the Antitumor Effect of Paclitaxel

被引：10
|
作者：
Xu, Xiaoyan [1 ]
Wu, Chao [1 ]
Bai, Andi [1 ]
Liu, Xuan [1 ]
Lv, Huiling [1 ]
Liu, Ying [1 ]
机构：
[1] Jinzhou Med Univ, Pharm Sch, 40 Songpo Rd, Jinzhou 121000, Liaoning, Peoples R China
来源：
JOURNAL OF NANOMATERIALS | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
ANTIBODY FRAGMENT; BIODISTRIBUTION; ACID; NANOCARRIERS; EXPRESSION; MICELLES; EFFICACY; RELEASE;
D O I：
10.1155/2017/2069685
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The aim of this study was to prepare and characterize an innovative hepatocellular carcinoma-targeted therapeutic drug delivery system based on folate-PEG-mesoporous silica nanoparticles (FA-PEG-MSNs) loaded with paclitaxel (PTX). In vitro cell experiments and an in vivo antitumor efficacy study demonstrated that FA-PEG-MSNs-PTX produced significantly higher tumor inhibition compared with pure PTX and mesoporous silica nanoparticles loaded with paclitaxel (MSNs-PTX). The biodistribution investigation of PTX in nude mice revealed that the FA-PEG-MSNs-PTX could accumulate in tumors. Folic acid functionalized MSNs resulted in a good targeting effect, confirming that FA-PEG-MSNs-PTX is a promising tumor-targeted drug delivery system for liver cancer chemotherapy.
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收藏
页数：13
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