A new inorganic photolabile protecting group for highly efficient visible light GABA uncaging

被引：88

作者：

Zayat, Leonardo

Noval, Maria G.

Campi, Julieta

Calero, Cecilia I.

Calvo, Daniel J.

Etchenique, Roberto

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Inorgan Analit & Quim Fis, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet & Biol Mol, RA-1428 Buenos Aires, DF, Argentina

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 17期

关键词：

cage compounds; gamma-aminobutyric acid; GABA; photolysis; ruthenium;

D O I：

10.1002/cbic.200700354

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An inorganic-based caged compound of the inhibitory neurotransmitter, gamma-amino butyric acid (GABA), was prepared and photolysed by light at 450 nm with the highest uncaging quantum yield reported to date. GABA ion channels were activated by irradiation in a biological preparation by using this caged compound.

引用

页码：2035 / 2038

页数：4

共 22 条

[1] Dendritic spines linearize the summation of excitatory potentials [J].

Araya, Roberto ;

Eisenthal, Kenneth B. ;

Yuste, Rafael .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (49) :18799-18804

[2] Topographic specificity of functional connections from hippocampal CA3 to CA1 [J].

Brivanlou, IH ;

Dantzker, JLM ;

Stevens, CF ;

Callaway, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (08) :2560-2565

[3] Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters [J].

Canepari, M ;

Nelson, L ;

Papageorgiou, G ;

Corrie, JET ;

Ogden, D .

JOURNAL OF NEUROSCIENCE METHODS, 2001, 112 (01) :29-42

[4] Circuitry of rat barrel cortex investigated by infrared-guided laser stimulation [J].

Dodt, HU ;

Schierloh, A ;

Eder, M ;

Zieglgänsberger, W .

NEUROREPORT, 2003, 14 (04) :623-627

[5] PHOTOCHEMISTRY OF RU(BPY)32+ [J].

DURHAM, B ;

CASPAR, JV ;

NAGLE, JK ;

MEYER, TJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (18) :4803-4810

[6]

Eder M, 2002, J NEUROSCI, V22, P7558

[7] SYNTHESIS AND PHOTOCHEMISTRY OF A NEW PHOTOLABILE DERIVATIVE OF GABA - NEUROTRANSMITTER RELEASE AND RECEPTOR ACTIVATION IN THE MICROSECOND TIME REGION [J].

GEE, KR ;

WIEBOLDT, R ;

HESS, GP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (18) :8366-8367

[8] Investigation of the α1-glycine receptor channel-opening kinetics in the submillisecond time domain [J].

Grewer, C .

BIOPHYSICAL JOURNAL, 1999, 77 (02) :727-738

[9] OXIDATION OF PRIMARY AMINES BOUND TO BIS(2,2'-BIPYRIDINE)RUTHENIUM(II) [J].

KEENE, FR ;

SALMON, DJ ;

MEYER, TJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (07) :1884-1889

[10] Integrative properties of radial oblique Dendrites in hippocampal CA1 pyramidal neurons [J].

Losonczy, A ;

Magee, JC .

NEURON, 2006, 50 (02) :291-307

← 1 2 3 →