AMPK activation increases postoperative cognitive impairment in intermittent hypoxia rats via direct activating PAK2

被引：7

作者：

Mei, Xi ^{[1
]}

Tan, Guolin ^{[2
]}

Qing, Wenxiang ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 3, Dept Anesthesiol, Changsha, Peoples R China

[2] Cent South Univ, Xiangya Hosp 3, Dept Otolaryngol Head & Neck Surg, Changsha, Peoples R China

来源：

BEHAVIOURAL BRAIN RESEARCH | 2020年 / 379卷

基金：

中国国家自然科学基金;

关键词：

Postoperative cognitive impairment; AMPK; Obstructive sleep apnea-hypopnea syndrome; PAK2; Neuroinflammation; OBSTRUCTIVE SLEEP-APNEA; HIPPOCAMPAL SYNAPTIC PLASTICITY; DELIRIUM; INHIBITION; GLUA1;

D O I：

10.1016/j.bbr.2019.112344

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The pathogenesis of postoperative cognitive impairment of obstructive sleep apnea-hypopnea syndrome (OSAHS) individuals remains unclear. AMP activated protein kinase (AMPK) is a ubiquitous sensor/effector of cell stresses. Thus we detected the role and underlying mechanisms of AMPK in postoperative cognitive impairment of OSAHS individuals in intermittent hypoxia rats. Cognitive function was evaluated by novel object recognition test and Barnes maze during the first 4 days after laparotomy. We found that laparotomy induced postoperative cognitive impairment and AMPK activation in intermittent hypoxia rats, but not in adult rats. Inhibiting AMPK activation via Compound C during laparotomy improved postoperative cognitive impairment and alleviated surgery-induced upregulation of p-PAK2, AMPK-PAK2 complex, and neuroinflammation (marked by microglial activation and IL-1 beta level) in intermittent hypoxia rats. These data suggested that AMPK played an important role in postoperative cognitive impairment of OSAHS individuals via directly activating PAK2.

引用

页数：7

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