Knockdown of hsa_circ_0001964 inhibits hepatocellular carcinoma cell proliferation by inactivating PI3K/AKT signaling pathway

被引:0
|
作者
Li, Liao [1 ]
Miao, Changfeng [2 ]
Peng, Shayong [1 ]
Jiang, Yu [1 ]
Lu, Xinchun [1 ]
机构
[1] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Gen Surg Branch 5, Changsha, Hunan, Peoples R China
[2] Hunan Normal Univ, Affiliated Hosp 1, Hunan Prov Peoples Hosp, Neurosurg Branch 2, Changsha, Hunan, Peoples R China
关键词
hsa_circ_0001964; Hepatocellular carcinoma; PI3K; AKT; Carcinogenesis; CIRCRNA; EXPRESSION; APOPTOSIS; MIGRATION; INVASION; RNA;
D O I
10.1007/s13273-021-00185-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background Circular RNAs (CircRNAs) play vital roles in the pathogenesis of hepatocellular carcinoma (HCC). However, the exact role and detailed mechanism of hsa_circ_0001964 during HCC carcinogenesis remains unknown. Objective To explore the expression, role and mechanism of hsa_circ_0001964 in HCC. Result The results indicated that the mRNA expression of hsa_circ_0001964 was upregulated in HCC cell lines and tissues, respectively, and hsa_circ_0001964 knockdown inhibited HCC cell proliferation in vitro. Western blot analysis showed that hsa_circ_0001964 knockdown suppressed the activation of the PI3K/AKT signaling pathway and its downstream factors (including c-Jun, c-Myc, and CCND1). Conclusion The results of the present study suggested that hsa_circ_0001964 may correlate with HBV infection, and it promotes HCC carcinogenesis via the PI3K/AKT signaling pathway. The findings of the present study provide important insights into the molecular mechanisms of HCC initiation, which may help to develop new treatment strategies against HCC.
引用
收藏
页码:185 / 191
页数:7
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