Insulin-like growth factor 1 inhibits glucocorticoid-induced glutamine synthetase activity in cultured L6 rat skeletal muscle cells

被引：10

作者：

Kimura, K ^{[1
]}

Kanda, F ^{[1
]}

Okuda, S ^{[1
]}

Chihara, K ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Med, Div 3,Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 302卷 / 2-3期

关键词：

insulin-like growth factor 1; glucocorticoid; steroid myopathy; glutamine synthetase activity; skeletal muscle;

D O I：

10.1016/S0304-3940(01)01667-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We previously demonstrated the preventive effect of insulin-like growth factor 1 (IGF-1) on steroid myopathy in rats. However, the mechanism by which IGF-1 inhibits steroid myopathy remains unclear. Recent studies have revealed that glutamine synthetase (GS) is induced by glucocorticoid and may be related to the development of steroid myopathy. In this study, we examined whether IGF-1 affected steroid-induced enhancement of GS activity in L6 rat skeletal muscle cells. Dexamethasone(10(-6) M) significantly increased GS activity in L6 cells(P < 0.01), IGF-1 dose-dependently inhibited dexamethasone-induced GS activity. Addition of IGF-1 (750 ng/ml) decreased GS activity to approximately 50% of that with dexamethasone alone (P < 0.01). These results suggest that a decrease in GS activity may be involved in the preventive effect of IGF-1 on steroid myopathy. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：154 / 156

页数：3

共 50 条

[41] REGENERATING SKELETAL-MUSCLE CELLS EXPRESS INSULIN-LIKE GROWTH FACTOR-I
JENNISCHE, E
HANSSON, HA
ACTA PHYSIOLOGICA SCANDINAVICA, 1987, 130 (02): : 327 - 332
[42] Gene expression patterns of the insulin-like growth factor system in cardiac & skeletal muscle cells
Shimada, M
Böhm, S
Schaper, W
Zimmermann, R
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (06) : A111 - A111
[43] THE EFFECTS OF GROWTH-HORMONE AND INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II ON GLUTAMINE-METABOLISM BY SKELETAL-MUSCLE OF THE RAT INVITRO
PARRYBILLINGS, M
BEVAN, SJ
OPARA, E
LIU, CT
DUNGER, DB
NEWSHOLME, EA
HORMONE AND METABOLIC RESEARCH, 1993, 25 (05) : 243 - 245
[44] Insulin and insulin-like growth factor-1 action on human skeletal muscle: Preferential effects of insulin-like growth factor-1 in type 2 diabetic subjects
Ciaraldi, TP
Carter, L
Rehman, N
Mohideen, P
Mudaliar, S
Henry, RR
METABOLISM-CLINICAL AND EXPERIMENTAL, 2002, 51 (09): : 1171 - 1179
[45] Glucocorticoid receptor function suppresses insulin-like growth factor 1 activity in human KLE endometrial-like cells
Lembessis, P
Kalariti, N
Koutsilieris, M
IN VIVO, 2004, 18 (01): : 43 - 47
[46] Hydrogen sulfide disrupts insulin-induced glucose uptake in L6 skeletal muscle cells
Donoso-Barraza, Camila
Borquez, Juan Carlos
Sepulveda, Carlos
Diaz-Castro, Francisco
Sepulveda-Quinenao, Claudia
Rodriguez, Juan Manuel
Porras, Omar
Troncoso, Rodrigo
FOOD AND CHEMICAL TOXICOLOGY, 2022, 165
[47] Glucocorticoid-induced growth arrest of lung alveolar epithelial cells is associated with increased production of insulin-like growth factor binding protein-2
Mouhieddine, OB
Cazals, V
Kuto, E
LeBouc, Y
Clement, A
ENDOCRINOLOGY, 1996, 137 (01) : 287 - 295
[48] ICF-I inhibited steroid-induced glutamine synthetase activity in rat skeletal muscle cells
Kanda, F
Kimura, K
Matsushita, T
Nakazawa, K
Ishihara, H
Okuda, S
Chihara, K
NEUROLOGY, 2000, 54 (07) : A439 - A440
[49] ETHANOL INHIBITS INSULIN-LIKE GROWTH FACTOR-1-MEDIATED SIGNALING AND PROLIFERATION OF C6 RAT GLIOBLASTOMA CELLS
RESNICOFF, M
RUBINI, M
BASERGA, R
RUBIN, R
LABORATORY INVESTIGATION, 1994, 71 (05) : 657 - 662
[50] AUGMENTATION OF THE EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTORS-I AND FACTOR-II ON GLUCOSE-UPTAKE IN CULTURED RAT SKELETAL-MUSCLE CELLS BY SULFONYLUREAS
WANG, PH
BEGUINOT, F
SMITH, RJ
DIABETOLOGIA, 1987, 30 (10) : 797 - 803

← 1 2 3 4 5 →