CO-INHIBITION OF p110α AND p110β IS REQUIRED FOR SUSTAINED PI3K SUPPRESSION

被引：0

作者：

不详

机构：

来源：

CANCER DISCOVERY | 2015年 / 5卷 / 02期

关键词：

D O I：

10.1158/2159-8290.CD-RW2015-003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：105 / 105

页数：1

共 2 条

[1] Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer [J].

Costa, Carlotta ;

Ebi, Hiromichi ;

Martini, Miriam ;

Beausoleil, Sean A. ;

Faber, Anthony C. ;

Jakubik, Charles T. ;

Huang, Alan ;

Wang, Youzhen ;

Nishtala, Madhuri ;

Hall, Ben ;

Rikova, Klarisa ;

Zhao, Jean ;

Hirsch, Emilio ;

Benes, Cyril H. ;

Engelman, Jeffrey A. .

CANCER CELL, 2015, 27 (01) :97-108

[2] Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ [J].

Schwartz, Sarit ;

Wongvipat, John ;

Trigwell, Cath B. ;

Hancox, Urs ;

Carver, Brett S. ;

Rodrik-Outmezguine, Vanessa ;

Will, Marie ;

Yellen, Paige ;

de Stanchina, Elisa ;

Baselga, Jose ;

Scher, Howard I. ;

Barry, Simon T. ;

Sawyers, Charles L. ;

Chandarlapaty, Sarat ;

Rosen, Neal .

CANCER CELL, 2015, 27 (01) :109-122

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