The Roles of Lpar1 in Central Nervous System Disorders and Diseases

被引：19

作者：

Xiao, Dongqiong ^{[1
,2
]}

Su, Xiaojuan ^{[1
]}

Gao, Hu ^{[2
]}

Li, Xihong ^{[2
]}

Qu, Yi ^{[1
]}

机构：

[1] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Dept Pediat,Minist Educ, Chengdu, Peoples R China

[2] Sichuan Univ, West China Second Univ Hosp, Dept Emergency, Minist Educ,Key Lab Birth Defects & Related Dis W, Chengdu, Peoples R China

来源：

FRONTIERS IN NEUROSCIENCE | 2021年 / 15卷

基金：

中国国家自然科学基金;

关键词：

Lpar1; Edg2; astroglia; microglia; oligodendrocyte; astrocyte; LYSOPHOSPHATIDIC ACID RECEPTOR; NEURAL STEM-CELLS; LPA(1) RECEPTOR; BLOOD BIOMARKERS; GENE-EXPRESSION; DEFICIENT MICE; ACTIVATION; PROTEIN; BRAIN; OLIGODENDROCYTES;

D O I：

10.3389/fnins.2021.710473

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lysophosphatidic acid receptor 1 (Lpar1), which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis. Endothelial differentiation gene-2 receptor (Edg2), the protein encoded by the Lpar1 gene, is present on various cell types in the central nervous system (CNS), such as neural stem cells (NSCs), oligodendrocytes, neurons, astrocytes, and microglia. Lpar1 deletion causes neurodevelopmental disorders and CNS diseases, such as brain cancer, neuropsychiatric disorders, demyelination diseases, and neuropathic pain. Here, we summarize the possible roles and mechanisms of Lpar1/Edg2 in CNS disorders and diseases and propose that Lpar1/Edg2 might be a potential therapeutic target for CNS disorders and diseases.

引用

页数：13

共 81 条

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