Synthetic, semisynthetic and natural analogues of peloruside A

被引：16
|
作者：
Brackovic, Amira [1 ]
Harvey, Joanne E. [1 ]
机构：
[1] Victoria Univ Wellington, Ctr Biodiscovery, Sch Chem & Phys Sci, Wellington 6140, New Zealand
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 23期
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; MICROTUBULE-STABILIZING AGENTS; STEREOSELECTIVE-SYNTHESIS; FRAGMENT; (+)-PELORUSIDE; LAULIMALIDE; SUBUNIT;
D O I：
10.1039/c4cc09785h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Peloruside A is a macrocyclic natural product from a New Zealand marine sponge Mycale hentscheli. It has attracted significant attention in the synthetic chemistry, cellular and structural biology communities due to its complex structure and potent anticancer activity. Several natural congeners have since been isolated and synthetic analogues have been prepared. This review describes in detail the published syntheses of peloruside analogues and discusses the structure-activity relationships available to date.
引用
收藏
页码：4750 / 4765
页数：16
相关论文
共 50 条
  • [41] Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones
    Aluru, Rammohan
    Mukherjee, Anindita
    Zyryanov, Grigory V.
    Majee, Adinath
    Santra, Sougata
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2023, 45 (10) : 8461 - 8475
  • [42] Simple, tunable synthetic routes to cannabinoid natural product analogues
    Navaratne, Primali
    Grenning, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [43] Synthetic investigations towards polypeptide natural products and xenortide analogues
    Wickman, Malachi
    Beecher, Jacob
    Leggans, Erick
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [44] SEMISYNTHETIC AND SYNTHETIC MACROMOLECULES IN IMMUNOCHEMICAL RESEARCH
    RUDE, E
    HIMMELSP.K
    SORG, C
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1969, 8 (05) : 388 - &
  • [45] Bioactive natural and semisynthetic latrunculins
    El Sayed, KA
    Youssef, DTA
    Marchetti, D
    JOURNAL OF NATURAL PRODUCTS, 2006, 69 (02): : 219 - 223
  • [46] NEW SEMISYNTHETIC AND NATURAL CEPHALOSPORINS
    ROZENFELD, GS
    ANTIBIOTIKI I MEDITSINSKAYA BIOTEKHNOLOGIYA, 1987, 32 (11): : 869 - 878
  • [47] Synthetic, Natural, and Semisynthetic Polymer Carriers for Controlled Nitric Oxide Release in Dermal Applications: A Review
    Gutierrez Cisneros, Carolina
    Bloemen, Veerle
    Mignon, Arn
    POLYMERS, 2021, 13 (05) : 1 - 26
  • [48] Cytotoxic Spliceostatins from Burkholderia sp and Their Semisynthetic Analogues
    He, Haiyin
    Ratnayake, Anokha S.
    Janso, Jeffrey E.
    He, Min
    Yang, Hui Y.
    Loganzo, Frank
    Shor, Boris
    O'Donnell, Christopher J.
    Koehn, Frank E.
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (08): : 1864 - 1870
  • [49] Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes
    Markley, Jana L.
    Fang, Luting
    Gasparrini, Andrew J.
    Symister, Chanez T.
    Kumar, Hirdesh
    Tolia, Niraj H.
    Dantas, Gautam
    Wencewicz, Timothy A.
    ACS INFECTIOUS DISEASES, 2019, 5 (04): : 618 - 633
  • [50] Natural compounds of the strobilurin series and their synthetic analogues as cell respiration inhibitors
    Zakharychev, VV
    Kovalenko, LV
    USPEKHI KHIMII, 1998, 67 (06) : 595 - 605
12345