Synthetic, semisynthetic and natural analogues of peloruside A

被引：16
|
作者：
Brackovic, Amira [1 ]
Harvey, Joanne E. [1 ]
机构：
[1] Victoria Univ Wellington, Ctr Biodiscovery, Sch Chem & Phys Sci, Wellington 6140, New Zealand
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 23期
关键词：
ENANTIOSELECTIVE TOTAL-SYNTHESIS; MICROTUBULE-STABILIZING AGENTS; STEREOSELECTIVE-SYNTHESIS; FRAGMENT; (+)-PELORUSIDE; LAULIMALIDE; SUBUNIT;
D O I：
10.1039/c4cc09785h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Peloruside A is a macrocyclic natural product from a New Zealand marine sponge Mycale hentscheli. It has attracted significant attention in the synthetic chemistry, cellular and structural biology communities due to its complex structure and potent anticancer activity. Several natural congeners have since been isolated and synthetic analogues have been prepared. This review describes in detail the published syntheses of peloruside analogues and discusses the structure-activity relationships available to date.
引用
收藏
页码：4750 / 4765
页数：16
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