MHC variation and risk of childhood B-cell precursor acute lymphoblastic leukemia

被引：18

作者：

Hosking, Fay J. ^{[1
]}

Leslie, Stephen ^{[2
]}

Dilthey, Alexander ^{[2
]}

Moutsianas, Loukas ^{[2
]}

Wang, Yufei ^{[1
]}

Dobbins, Sara E. ^{[1
]}

Papaemmanuil, Elli ^{[1
]}

Sheridan, Eamonn ^{[3
]}

Kinsey, Sally E. ^{[4
]}

Lightfoot, Tracy ^{[5
]}

Roman, Eve ^{[5
]}

Irving, Julie A. E. ^{[6
]}

Allan, James M. ^{[6
]}

Taylor, Malcolm ^{[7
]}

Greaves, Mel ^{[8
]}

McVean, Gilean ^{[2
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

[3] St James Univ Hosp, Yorkshire Reg Genet Serv, Leeds LS9 7TF, W Yorkshire, England

[4] St James Univ Hosp, Dept Paediat & Adolescent Oncol & Haematol, Leeds LS9 7TF, W Yorkshire, England

[5] Univ York, Dept Hlth Sci, Epidemiol & Genet Unit, York YO10 5DD, N Yorkshire, England

[6] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[7] Univ Manchester, St Marys Hosp, Sch Canc & Enabling Sci, Canc Immunogenet Grp, Manchester M13 0JH, Lancs, England

[8] Inst Canc Res, Sect Haematooncol, Sutton SM2 5NG, Surrey, England

来源：

BLOOD | 2011年 / 117卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HLA ALLELES; SUSCEPTIBILITY; ASSOCIATION; HLA-DPB1-ASTERISK-0201; ETIOLOGY; DISEASE;

D O I：

10.1182/blood-2010-08-301598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A role for specific human leukocyte antigen (HLA) variants in the etiology of childhood acute lymphoblastic leukemia (ALL) has been extensively studied over the last 30 years, but no unambiguous association has been identified. To comprehensively study the relationship between genetic variation within the 4.5 Mbmajor histocompatibility complex genomic region and precursor B-cell (BCP) ALL risk, we analyzed 1075 observed and 8176 imputed single nucleotide polymorphisms and their related haplotypes in 824 BCP-ALL cases and 4737 controls. Using these genotypes we also imputed bothcommonand rare alleles at class I (HLA-A, HLA-B, and HLA-C) and class II (HLA-DRB1, HLA-DQA1, and HLA-DQB1) HLA loci. Overall, we found no statistically significant association between variants and BCP-ALLrisk. We conclude that major histocompatibility complex-defined variation in immune-mediated response is unlikely to be a major risk factor for BCP-ALL. (Blood. 2011; 117(5): 1633-1640)

引用

页码：1633 / 1640

页数：8

共 50 条

[1] Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia
V Enciso-Mora
F J Hosking
E Sheridan
S E Kinsey
T Lightfoot
E Roman
J A E Irving
I P M Tomlinson
J M Allan
M Taylor
M Greaves
R S Houlston
Leukemia, 2012, 26 : 2212 - 2215
[2] Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia
Enciso-Mora, V.
Hosking, F. J.
Sheridan, E.
Kinsey, S. E.
Lightfoot, T.
Roman, E.
Irving, J. A. E.
Tomlinson, I. P. M.
Allan, J. M.
Taylor, M.
Greaves, M.
Houlston, R. S.
LEUKEMIA, 2012, 26 (10) : 2212 - 2215
[3] Expression of angiogenic factors in childhood B-cell precursor acute lymphoblastic leukemia
Stachel, Daniel
Albert, Michael
Meilbeck, Rita
Paulides, Marios
Schmid, Irene
ONCOLOGY REPORTS, 2007, 17 (01) : 147 - 152
[4] New genetics and diagnosis of childhood B-cell precursor acute lymphoblastic leukemia
Harrison, Christine
PEDIATRIC REPORTS, 2011, 3 : 5 - 7
[5] DIFFERENTIAL microRNA EXPRESSION IN CHILDHOOD B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
Ju, Xiuli
Li, Dong
Shi, Qing
Hou, Huaishui
Sun, Nianzheng
Shen, Baijun
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2009, 26 (01) : 1 - 10
[6] Altered neutrophil immunophenotypes in childhood B-cell precursor acute lymphoblastic leukemia
Oliveira, Elen
Bacelar, Thiago S.
Ciudad, Juana
Ribeiro, Maria Cecilia M.
Garcia, Daniela R. N.
Sedek, Lukasz
Maia, Simone F.
Aranha, Daniel B.
Machado, Indyara C.
Ikeda, Arissa
Baglioli, Bianca F.
Lopez-Duarte, Nathalia
Teixeira, Lisandra A. C.
Szczepanski, Tomasz
Silva, Maria Luiza M.
Land, Marcelo G. P.
Orfao, Alberto
Costa, Elaine S.
ONCOTARGET, 2016, 7 (17) : 24664 - 24676
[7] The age incidence of childhood B-Cell precursor acute lymphoblastic leukemia in Mexico city
Bernaldez Rios, R.
Alatoma Medina, N. E.
Flores Lujano, J.
Ortega Alvarez, M. C.
Perez Saldivar, M. L.
Mejia Arangure, J. M.
EPIDEMIOLOGY, 2008, 19 (01) : S218 - S218
[8] Neonatal Inflammatory Markers Are Associated with Childhood B-cell Precursor Acute Lymphoblastic Leukemia
Soegaard, Signe Holst
Rostgaard, Klaus
Skogstrand, Kristin
Wiemels, Joseph Leo
Schmiegelow, Kjeld
Hjalgrim, Henrik
CANCER RESEARCH, 2018, 78 (18) : 5458 - 5463
[9] Expression of osteopontin splicing isoforms in childhood B-cell precursor acute lymphoblastic leukemia
Santos da Fonseca Bastos, Ana Clara
Blunck Blunck, Caroline Barbieri
Ferreira, Luciana Bueno
Pombo-de-Oliveira, Maria do Socorro
Emerenciano, Mariana
Gimba, Etel R.
CANCER RESEARCH, 2018, 78 (13)
[10] JAK2 Aberrations in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Steeghs, Elisabeth M. P.
Jerchel, Isabel S.
de Goffau-Nobel, Willemieke
Hoogkamer, Alex Q.
Boer, Judith M.
Boeree, Aurelie
van de Ven, Cesca
Koudijs, Marco J.
Besselink, Nicolle J. M.
de Groot-Kruseman, Hester A.
Zwaan, C. Michel
Horstmann, Martin A.
Pieters, Rob
Den Boer, Monique L.
BLOOD, 2016, 128 (22)

← 1 2 3 4 5 →