Does whole-body vibration have benefits in patients with multiple sclerosis: a systematic review and meta-analysis

Purpose: To review and assess the effect of whole-body vibration in patients with multiple sclerosis. Method: We conducted a systematic review and meta-analysis of randomized controlled trials of whole-body vibration (WBV) in patients with multiple sclerosis (MS). Effect on mobility, balance, muscle strength, spasm, gait, fatigue, general well-being and side effects were evaluated. Results: Ten randomized controlled trials qualified the inclusion criteria. Meta-analysis revealed no significant benefit of WBV in Berg balance scale (standard mean difference [SMD], 0.06; 95% confidence interval [CI], -0.54 to 0.66; P = 0.85; I-2= 69%) and Timed Up and Go test (SMD, -0.15; 95% CI, -0.41 to 0.10; P = 0.24; I-2= 0%) when compared with outcomes in the control groups. A significant difference in muscle strength was observed in knee extensor (SMD, 0.43, 95% CI, 0.05 to 0.81; P = 0.03; I-2= 0%). There was no sufficient evidence of benefit of WBV in reducing spasm, relieving fatigue, improving gait or for enhancing well-being. Conclusion: Limited evidence supported the benefits of WBV therapy on functions of patients with multiple sclerosis. Larger and more high-quality trials are needed.