Signal-to-noise ratio analysis and improvement for fluorescence tomography imaging

被引：6

作者：

Wang, Huiquan ^{[1
,2
,3
]}

Feng, Xing ^{[1
]}

Shi, Boya ^{[1
,3
]}

Liang, Wenxuan ^{[2
]}

Chen, Yongping ^{[2
]}

Wang, Jinhai ^{[1
,3
]}

Li, Xingde ^{[2
]}

机构：

[1] Tianjin Polytech Univ, Sch Elect & Informat Engn, Tianjin 300387, Peoples R China

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA

[3] Tianjin Key Lab Optoelect Detect Technol & Syst, Tianjin 300387, Peoples R China

来源：

REVIEW OF SCIENTIFIC INSTRUMENTS | 2018年 / 89卷 / 09期

基金：

中国博士后科学基金; 美国国家卫生研究院;

关键词：

IN-VIVO; MOLECULAR TOMOGRAPHY; INDOCYANINE GREEN; X-RAY;

D O I：

10.1063/1.5045511

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

CCD-based fluorescence tomography is widely used for small animal whole-body imaging. In this report, systematic signal-to-noise ratio (SNR) analyses of a fluorescence tomography imaging (FTI) system were performed, resulting in an easy-to-follow strategy to optimize hardware configurations and operational conditions for acquiring high-quality imaging data and for improving the overall system performance. Phantom experiments were conducted to demonstrate the performance improvement by these optimizations. The improved performance was further verified by imaging a tumor-bearing mouse in vivo. This report provides general and practical guidelines for setting up a high-performance electron multiplying charge coupled device based FTI system to achieve an optimized SNR, which can be useful for future FTI technology development. Published by AIP Publishing.

引用

页数：10

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