CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression

被引：659

作者：

Sun, Xueqing ^{[1
]}

Cheng, Guangcun ^{[1
]}

Hao, Mingang ^{[1
]}

Zheng, Jianghua ^{[1
]}

Zhou, Xiaoming ^{[1
]}

Zhang, Jian ^{[2
]}

Taichman, Russell S. ^{[3
]}

Pienta, Kenneth J. ^{[2
]}

Wang, Jianhua ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Chinese Minist Educ,Inst Med Sci, Key Lab Cell Differentiat & Apoptosis, Dept Biochem & Mol & Cell Biol,Sch Med, Shanghai 200025, Peoples R China

[2] Univ Michigan, Dept Internal Med & Urol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Dent, Dept Periodont & Oral Med, Ann Arbor, MI 48109 USA

来源：

CANCER AND METASTASIS REVIEWS | 2010年 / 29卷 / 04期

关键词：

Chemokines; CXCL12; /; CXCR4; CXCR7; chemokine axis; Cancer progression; PROTEIN COUPLED RECEPTOR; COMPLEMENT COMPONENT C3; CELL-DERIVED FACTOR-1; FACTOR-I; BREAST-CANCER; STEM-CELLS; CXCR4; EXPRESSION; TUMOR-GROWTH; TRANSENDOTHELIAL MIGRATION; RHABDOMYOSARCOMA CELLS;

D O I：

10.1007/s10555-010-9256-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important alpha-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the trafficking of normal and malignant cells. For many years, it was believed that CXCR4 was the only receptor for CXCL12. Yet, recent work has demonstrated that CXCL12 also binds to another seven-transmembrane span receptor called CXCR7. Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Here, we review the current concepts regarding the role of CXCL12 / CXCR4 / CXCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CXCL12 to develop secondary tumors. We also summarize recent therapeutic approaches to target these receptors and/or their ligands.

引用

页码：709 / 722

页数：14

共 139 条

[1] The chemokine SDF-1 is a chemoattractant for human CD34(+) hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34(+) progenitors to peripheral blood [J].