Anti-herpesvirus activity of an extract of Ribes nigrum L.

被引：34

作者：

Suzutani, T ^{[1
]}

Ogasawara, M ^{[1
]}

Yoshida, I ^{[1
]}

Azuma, M ^{[1
]}

Knox, YM ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Microbiol, Asahikawa, Hokkaido 0788510, Japan

来源：

PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 06期

关键词：

herpes simplex virus; varicella-zoster virus; Ribes nigrum L; anti-herpesvirus activity;

D O I：

10.1002/ptr.1207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An extract of Ribes nigrum L., known as blackcurrant in Europe and Kurokarin(R) in Japan, has been used as an ingredient in a variety of foods and folk medicine. In this study, the anti-herpesvirus activity of this extract was examined in vitro. The extract inhibited herpes simplex virus type I attachment on the cell membrane completely at a 100-fold dilution, as well as the plaque formation of herpes simplex virus types I and 2, and varicella-zoster virus by 50% at a 400-fold dilution or lower concentrations. This latter activity, which inhibits virus replication in cells, was due to the inhibition of protein synthesis in infected cells from the early stage of infection. Kurokarin is a possible candidate as a herbal medicine for herpesvirus infectious diseases. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：609 / 613

页数：5

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