Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers

被引：37

作者：

Zakharov, Valery P. ^{[1
]}

Bratchenko, Ivan A. ^{[1
]}

Artemyev, Dmitry N. ^{[1
]}

Myakinin, Oleg O. ^{[1
]}

Kornilin, Dmitry V. ^{[1
]}

Kozlov, Sergey V. ^{[2
]}

Moryatov, Alexander A. ^{[2
]}

机构：

[1] Samara State Aerosp Univ, Dept Laser & Biotech Syst, Samara 443086, Russia

[2] Samara State Med Univ, Dept Oncol, Samara 443099, Russia

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2015年 / 20卷 / 02期

关键词：

optical coherence tomography; Raman spectroscopy; optical diagnostics for medicine; spectroscopy; tissue diagnostics; ELASTIC-SCATTERING SPECTROSCOPY; COHERENCE TOMOGRAPHY; RAMAN-SPECTROSCOPY; DIAGNOSIS; MELANOMA; BIOPSY;

D O I：

10.1117/1.JBO.20.2.025003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and classification of tumors. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE).

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