CCDC98 targets BRCA1 to DNA damage sites

被引：133

作者：

Liu, Zixing ^{[1
]}

Wu, Jiaxue ^{[1
]}

Yu, Xiaochun ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Div Mol Med & Genet, Dept Internal Med, Ann Arbor, MI 48109 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 08期

关键词：

D O I：

10.1038/nsmb1279

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Breast cancer-1 (BRCA1) participates in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. Recently, we have demonstrated that a ubiquitin-binding protein, RAP80, is required for DNA damage-induced BRCA1 translocation. Here we identify another component, CCDC98, in the BRCA1-RAP80 complex. CCDC98 mediates BRCA1's association with RAP80. Moreover, CCDC98 controls both DNA damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Together, our results demonstrate that CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.

引用

页码：716 / 720

页数：5

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