Titanium(IV)-mediated synthesis of 2,3-diisothiocyanato-succinic acid diesters and 3,6-dithioxo-piperazine derivatives

被引：11

作者：

Ciez, Dariusz ^{[1
]}

机构：

[1] Jagiellonian Univ, Dept Organ Chem, PL-30060 Krakow, Poland

来源：

TETRAHEDRON | 2007年 / 63卷 / 21期

关键词：

D O I：

10.1016/j.tet.2007.03.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidative homocoupling of titanium(IV) enolates of 2-isothiocyanato-carboxylic esters resulted in the synthesis of 2,3-diisothiocyanato-succinic acid diesters. The reactions were carried out using DIPEA/TiCl4 oxidizing system and led to chiral dimers (instead of meso) as main products. Titanium(IV) enolates derived from hindered 2-isothiocyanato-carboxylates did not undergo the oxidative homocoupling but gave 3,6-dithioxo-piperazines. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4510 / 4515

页数：6

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