Leptin in inflammation and autoimmunity

被引：253
作者：
La Cava, Antonio [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, 1000 Vet Ave 32-59, Los Angeles, CA 90095 USA
来源：
CYTOKINE | 2017年 / 98卷
基金：
美国国家卫生研究院;
关键词：
Leptin; Inflammation; Autoimmunity; SYSTEMIC-LUPUS-ERYTHEMATOSUS; REGULATORY T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; BLOOD MONONUCLEAR-CELLS; PLASMA LEPTIN; SERUM LEPTIN; IMMUNE-RESPONSES; OB/OB MICE; IN-VIVO; STIMULATES PROLIFERATION;
D O I：
10.1016/j.cyto.2016.10.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response. This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：51 / 58
页数：8
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