Potential roles of insulin and IGF-1 in Alzheimer's disease

被引：224
作者：
Gasparini, L
Xu, HX
机构：
[1] Nicox Res Inst, I-20091 Milan, Italy
[2] Rockefeller Univ, Fisher Ctr Res Alzheimer Dis, New York, NY 10021 USA
来源：
TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 08期
关键词：
D O I：
10.1016/S0166-2236(03)00163-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.
引用
收藏
页码：404 / 406
页数：3
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