Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma

被引：6
作者：
Bourouba, Mehdi [1 ]
Boukercha, Aziza [1 ]
Zergoun, Ahmed-Amine [1 ]
Zebboudj, Abderezak [1 ]
Elhadjan, Mohamed [2 ]
Djenaoui, Djamel [2 ]
Asselah, Fatima [3 ]
Touil-Boukoffa, Chafia [1 ]
机构：
[1] USTHB, Fac Biol Sci, Lab Cell & Mol Biol LBCM, Team Cytokines & Nitr Oxide synthases, Algiers, Algeria
[2] Mustapha Pacha Hosp, Fac Med, Otorhynolaryngol Dept, Algiers, Algeria
[3] Mustapha Pacha Hosp, Fac Med, Anatomopathol Dept, Algiers, Algeria
来源：
BIOMARKERS | 2012年 / 17卷 / 07期
关键词：
Nasopharyngeal carcinoma; UCNT; nitric oxide; biomarker; inflammation; carcinogenesis; ACTIVATED PROTEIN-KINASES; INFILTRATING LYMPHOCYTES; EPITHELIAL-CELLS; CANCER-RISK; DNA-DAMAGE; SYNTHASE; EXPRESSION; P53; INFLAMMATION; ASSOCIATION;
D O I：
10.3109/1354750X.2012.706643
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nasopharyngeal carcinoma (NPC) is thought to arise because of chronic inflammation. The correlation between nitric oxide (NO) production, a biomarker of inflammation and NPC development remains unexplored. To investigate this question, we performed a profile analysis on plasma collected from untreated, treated, remissive, cured and relapsing patients. Nitrites were measured to assess NO activity. We observed that increased nitrites concentrations in untreated and relapsing patients associated with tumor development. Moreover, nitrites levels were similar in remissive, cured and healthy individuals. Altogether, our results suggest that NO might be an interesting blood biomarker to monitor tumor growth in NPC patients.
引用
收藏
页码：618 / 624
页数：7
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