A new pancreatic lipase inhibitor from Broussonetia kanzinoki

被引：41

作者：

Ahn, Jong Hoon ^{[1
]}

Liu, Qing ^{[1
]}

Lee, Chul ^{[1
]}

Ahn, Mi-Jeong ^{[2
]}

Yoo, Hwan-Soo ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

Lee, Mi Kyeong ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

[2] Gyeongsang Natl Univ, Coll Pharm, Jinju 660751, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Broussonetia kanzinoki; Moraceae; Pancreatic lipase; Broussonone Lambda; Adipocyte differentiation; ORLISTAT; OBESITY;

D O I：

10.1016/j.bmcl.2012.02.088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4 '-dihydroxyflavan (4), 3 ',7-dihydroxy-4 '-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4 '-methoxyflavone (6), 3,7,3 '-trihydroxy-4 '-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC50 of 28.4 mu M. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2760 / 2763

页数：4

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