Cytocompatibility of nano-hydroxyapatite/polyetheretherketone composite materials with Sprague Dawley rat osteoblasts

被引：4

作者：

Wang, L. ^{[1
,2
,3
]}

Huang, F. J. ^{[1
]}

Wu, Z. Z. ^{[1
,2
,4
]}

Qin, J. ^{[3
]}

Wang, C. B. ^{[1
]}

Xie, M. Z. ^{[4
]}

机构：

[1] Second Peoples Hosp Shenzhen City, Shenzhen 518035, Peoples R China

[2] Shenzhen Inst Geriatr, Shenzhen 518020, Peoples R China

[3] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Peoples R China

[4] Digital Chinese Med 2011 Collaborat Innovat Ctr C, Changsha 410007, Hunan, Peoples R China

来源：

MATERIALS TECHNOLOGY | 2016年 / 31卷

关键词：

Nano-hydroxyapatite; Polyetheretherketone; Composite; Osteoblasts; Cytocompatibility; MECHANICAL-PROPERTIES; HYDROXYAPATITE; IMPLANTS;

D O I：

10.1080/10667857.2016.1192371

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The growth and alkaline phosphatase (ALP) activities of Sprague Dawley(SD) rat osteoblasts cultured in the nano-hydroxyapatite/polyetheretherketone (n-HA/PEEK) composite extracts and on the surfaces of these composites were investigated in this study. The osteoblasts of 24-h-old SD rats were cultured by modified enzymatic digestion in vitro. The ALP activities of the SD osteoblasts cultured in n-HA/PEEK composite extracts were measured and the mineralisation was studied by alizarin red staining. The morphological characteristics of the SD osteoblasts incubated on the n-HA/PEEK composite surfaces were observed by scanning electron microscopy and the ALP activity was also detected. The results showed that the n-HA/PEEK composites have good cytocompatibility with the SD osteoblasts and there were no obvious differences between PEEK and n-HA/PEEK composites in ALP activities and mineralisation of the SD osteoblasts cultured in their extracts. N-HA/PEEK composites could promote the growth of the SD osteoblasts on the surfaces of them and the improvement was related to the content and uniform distribution of n-HA in the n-HA/PEEK composites. The 5vol.% n-HA/PEEK composites was promising to be used for bone substitute materials.

引用

页码：28 / 32

页数：5

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