One Pot Multicomponent Biginelli Reaction Employing Ionic Liquids as an Organocatalyst

被引：11
作者：
Shaikh, Tanveer M. [1 ]
Nagarajan, Sankaranarayanan [2 ]
Kandasamy, Elango [3 ]
机构：
[1] Mekelle Univ, Dept Chem, CNCS, Mekele, Ethiopia
[2] PSN Engn Coll, Dept Sci & Humanities, Mela Thediyoor, Tirunelveli, India
[3] Amrita Vishwa Vidyapeetham, Dept Sci, Dhanvanthri Lab, Amrita Sch Engn Coimbatore, Coimbatore, Tamil Nadu, India
来源：
CURRENT ORGANOCATALYSIS | 2020年 / 7卷 / 02期
关键词：
Biginelli reaction; multicomponent; Ionic liquid; organocatalyst; dihydropyrimidinones; dihydropyrimidinthiones; MAGNETICALLY RECOVERABLE CATALYST; CALCIUM-CHANNEL BLOCKERS; SOLVENT-FREE SYNTHESIS; EFFICIENT SYNTHESIS; CONDENSATION REACTION; RECYCLABLE CATALYST; FE3O4; NANOPARTICLES; IMPROVED PROTOCOL; ACID-ESTERS; DIHYDROPYRIMIDINONES;
D O I：
10.2174/2213337206666191001214521
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Introduction: The N-heterocyclic compounds have been extensively studied in pharmaceutical industries. Furthermore, syntheses of such compounds employing organo-catalyst have been associated with sustainable technology. Methods: The synthesis of new, stable ionic liquids and their catalytic applications in one-pot multicomponent Biginelli reaction is presented. The method provides broad substrate scope, yielding the corresponding 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones, in good to excellent yields, respectively. Results and Conclusion: The developed reactions are associated with certain advantages, short reaction time and sustainable conditions. The protocol has advantages eco-friendly procedure, recovery and reusability of catalyst, which showed consistent activity.
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收藏
页码：96 / 107
页数：12
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