Regulation of epithelial immunity by IL-17 family cytokines

被引：119

作者：

Pappu, Rajita ^{[1
]}

Rutz, Sascha ^{[1
]}

Ouyang, Wenjun ^{[1
]}

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 07期

关键词：

epithelial cells; IL-17; cytokines; immunity; INNATE LYMPHOID-CELLS; TISSUE-INDUCER CELLS; T-CELLS; HOST-DEFENSE; HETERODIMERIC CYTOKINE; ADAPTIVE IMMUNITY; MUCOSAL IMMUNITY; RECEPTOR COMPLEX; TH2; RESPONSES; EXPRESSION;

D O I：

10.1016/j.it.2012.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cutaneous and mucosal epithelial cells function as both a physical barrier and as immune sentinels against environmental challenges, such as microbial pathogens, allergens and stress. The crosstalk between epithelial cells and leukocytes is essential for orchestrating proper immune responses during host defense. Interleukin (IL)-17 family cytokines are important players in regulating innate epithelial immune responses. Although IL-17A and IL-17F promote antibacterial and antifungal responses, IL-17E is essential for defense against parasitic infections. Emerging data indicate that another member of this family, IL-17C, specifically regulates epithelial immunity. IL-17C production serves as an immediate defense mechanism by epithelial cells, utilizing an autocrine mechanism to promote antibacterial responses at barrier surfaces.

引用

页码：343 / 349

页数：7

共 66 条

[11] Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2 [J].

Crellin, Natasha K. ;

Trifari, Sara ;

Kaplan, Charles D. ;

Satoh-Takayama, Naoko ;

Di Santo, James P. ;

Spits, Hergen .

IMMUNITY, 2010, 33 (05) :752-764

[12] Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells [J].

Cupedo, Tom ;

Crellin, Natasha K. ;

Papazian, Natalie ;

Rombouts, Elwin J. ;

Weijer, Kees ;

Grogan, Jane L. ;

Fibbe, Willem E. ;

Cornelissen, Jan J. ;

Spits, Hergen .

NATURE IMMUNOLOGY, 2009, 10 (01) :66-74

[13]

Davies Donna E, 2009, Proc Am Thorac Soc, V6, P678, DOI 10.1513/pats.200907-067DP

[14] An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells [J].

Eberl, G ;

Marmon, S ;

Sunshine, MJ ;

Rennert, PD ;

Choi, YW ;

Littman, DR .

NATURE IMMUNOLOGY, 2004, 5 (01) :64-73

[15] Mechanisms of interieukin-1β release [J].

Eder, Claudia .

IMMUNOBIOLOGY, 2009, 214 (07) :543-553

[16] Structural basis of receptor sharing by interleukin 17 cytokines [J].

Ely, Lauren K. ;

Fischer, Suzanne ;

Garcia, K. Christopher .

NATURE IMMUNOLOGY, 2009, 10 (12) :1245-U3

[17] Structure and signalling in the IL-17 receptor family [J].

Gaffen, Sarah L. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (08) :556-567

[18] New IL-17 family members promote Th1 or Th2 responses in the lung: In vivo function of the novel cytokine IL-25 [J].

Hurst, SD ;

Muchamuel, T ;

Gorman, DM ;

Gilbert, JM ;

Clifford, T ;

Kwan, S ;

Menon, S ;

Seymour, B ;

Jackson, C ;

Kung, TT ;

Brieland, JK ;

Zurawski, SM ;

Chapman, RW ;

Zurawski, G ;

Coffman, RL .

JOURNAL OF IMMUNOLOGY, 2002, 169 (01) :443-453

[19] IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding [J].

Hymowitz, SG ;

Filvaroff, EH ;

Yin, JP ;

Lee, J ;

Cai, LP ;

Risser, P ;

Maruoka, M ;

Mao, WG ;

Foster, J ;

Kelley, RF ;

Pan, GH ;

Gurney, AL ;

de Vos, AM ;

Starovasnik, MA .

EMBO JOURNAL, 2001, 20 (19) :5332-5341

[20] Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin [J].

Intlekofer, Andrew M. ;

Banerjee, Arnob ;

Takemoto, Naofumi ;

Gordon, Scott M. ;

DeJong, Caitlin S. ;

Shin, Haina ;

Hunter, Christopher A. ;

Wherry, E. John ;

Lindsten, Tullia ;

Reiner, Steven L. .

SCIENCE, 2008, 321 (5887) :408-411

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