The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

被引：21

作者：

Chen Xu'e ^{[1
]}

Liu Zhixiang ^{[1
]}

Yue Qing ^{[1
]}

Liu Houjun ^{[1
]}

Wu Yan ^{[1
]}

Li Jiawen ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2007年 / 27卷 / 06期

关键词：

TNF-alpha; ICAM-1; lichen planus;

D O I：

10.1007/s11596-007-0632-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to investigate the role of TNF-alpha and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-alpha and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.

引用

页码：739 / 741

页数：3

共 7 条

[1] Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis
Ackermann, L
Harvima, IT
[J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 1998, 290 (07) : 353 - 359
[2] Oral lichen planus: immunohistology of mucosal lesions
Dorrego, MV
Correnti, M
Delgado, R
Tapia, FJ
[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (07) : 410 - 414
[3] Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planes
Hirota, M
Ito, T
Okudela, K
Kawabe, R
Yazawa, T
Hayashi, H
Nakatani, Y
Fujita, K
Kitamura, H
[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (04) : 204 - 212
[4] The role of perforin-mediated apoptosis in lichen planus lesions
Kastelan, M
Massari, LP
Gruber, F
Zamolo, G
Zauhar, G
Coklo, M
Rukavina, D
[J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2004, 296 (05) : 226 - 230
[5] Overexpression of tumour necrosis factor-α-converting enzyme in psoriasis
Kawaguchi, M
Mitsuhashi, Y
Kondo, S
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (05) : 915 - 919
[6] TNF-α expression and apoptosis-regulating proteins in oral lichen planus:: a comparative immunohistochemical evaluation
Sklavounou, A
Chrysomali, E
Scorilas, A
Karameris, A
[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2000, 29 (08) : 370 - 375
[7] Expression of TNF-α in oral lichen planus treated with fluocinolone acetonide 0.1%
Thongprasom, K
Dhanuthai, K
Sarideechaigul, W
Chaiyarit, P
Chaimusig, M
[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2006, 35 (03) : 161 - 166

← 1 →