The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

被引：21

作者：

Chen Xu'e ^{[1
]}

Liu Zhixiang ^{[1
]}

Yue Qing ^{[1
]}

Liu Houjun ^{[1
]}

Wu Yan ^{[1
]}

Li Jiawen ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Dermatol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES | 2007年 / 27卷 / 06期

关键词：

TNF-alpha; ICAM-1; lichen planus;

D O I：

10.1007/s11596-007-0632-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to investigate the role of TNF-alpha and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-alpha and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.

引用

页码：739 / 741

页数：3

共 7 条

[1] Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis [J].

Ackermann, L ;

Harvima, IT .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 1998, 290 (07) :353-359

[2] Oral lichen planus: immunohistology of mucosal lesions [J].

Dorrego, MV ;

Correnti, M ;

Delgado, R ;

Tapia, FJ .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (07) :410-414

[3] Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planes [J].

Hirota, M ;

Ito, T ;

Okudela, K ;

Kawabe, R ;

Yazawa, T ;

Hayashi, H ;

Nakatani, Y ;

Fujita, K ;

Kitamura, H .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2002, 31 (04) :204-212

[4] The role of perforin-mediated apoptosis in lichen planus lesions [J].

Kastelan, M ;

Massari, LP ;

Gruber, F ;

Zamolo, G ;

Zauhar, G ;

Coklo, M ;

Rukavina, D .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2004, 296 (05) :226-230

[5] Overexpression of tumour necrosis factor-α-converting enzyme in psoriasis [J].

Kawaguchi, M ;

Mitsuhashi, Y ;

Kondo, S .

BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (05) :915-919

[6] TNF-α expression and apoptosis-regulating proteins in oral lichen planus:: a comparative immunohistochemical evaluation [J].

Sklavounou, A ;

Chrysomali, E ;

Scorilas, A ;

Karameris, A .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2000, 29 (08) :370-375

[7] Expression of TNF-α in oral lichen planus treated with fluocinolone acetonide 0.1% [J].

Thongprasom, K ;

Dhanuthai, K ;

Sarideechaigul, W ;

Chaiyarit, P ;

Chaimusig, M .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2006, 35 (03) :161-166

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