Camellia oil improves Aβ25-35-induced memory impairment by regulating the composition of the gut microbiota and lipid metabolism in mice

被引：10
|
作者：
Guo, Pengli [1 ,2 ]
Zeng, Mengnan [1 ,2 ]
Cao, Bing [1 ,2 ]
Liu, Meng [1 ,2 ]
Zhang, Yuhan [1 ,2 ]
Jia, Jufang [1 ,2 ]
Zhang, Qinqin [1 ,2 ]
Zhang, Beibei [1 ,2 ]
Wang, Ru [1 ,2 ]
Xiong, Weizheng [3 ]
Zheng, Xiaoke [1 ,2 ]
Feng, Weisheng [1 ,2 ]
机构：
[1] Henan Univ Chinese Med, 156 Jinshui East Rd, Zhengzhou 450046, Peoples R China
[2] Engn & Technol Ctr Chinese Med Dev Henan Prov, 156 Jinshui East Rd, Zhengzhou 450046, Peoples R China
[3] Henan Luda Camellia Oil Co Ltd, 59 Jiefang Rd, Xinyang 465550, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2022年 / 96卷
关键词：
Alzheimer?s disease; Camellia oil; Gut microbiota; Lipid metabolism; PPARs; MEDITERRANEAN DIET; ALZHEIMERS-DISEASE; MOUSE MODEL; BRAIN; NEUROINFLAMMATION; STRESS; MAZE; AXIS;
D O I：
10.1016/j.jff.2022.105214
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Camellia oil is a traditional Chinese medicine and a nutritional food, it is one of the best health foods for the prevention of Alzheimer's disease (AD). The aim of this study was to investigate the therapeutic effects of camellia oil in AD in terms of intestinal microbiota and lipid metabolism. To assess changes in mouse behavior, brain pathology, gut microbiota, PPARs receptors and lipid metabolism related proteins in brain tissue, immune cells, and levels of inflammation in the brain. The integrated results show camellia oil may improve memory impairment in mice by mediating in vivo immune cells and inflammation in the brain through PPARs, which further affect gut microbiota and lipid metabolism. These data provide pharmacological rationale for camellia oil in the treatment of AD and support its value as a nutritional food.
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页数：12
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