Galectin-3 in Heart Failure An Update of the Last 3 Years

被引：94

作者：

Gehlken, Carolin ^{[1
]}

Suthahar, Navin ^{[1
]}

Meijers, Wouter C. ^{[1
]}

de Boer, Rudolf A. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, POB 30-001, NL-9700 RB Groningen, Netherlands

来源：

HEART FAILURE CLINICS | 2018年 / 14卷 / 01期

关键词：

Galectin-3; Heart failure; Fibrosis; inhibitor; Biomarker; Prognosis; MODIFIED CITRUS PECTIN; PROGNOSTIC VALUE; CARDIOVASCULAR-DISEASE; MYOCARDIAL FIBROSIS; PREDICTIVE-VALUE; PERFORMANCE-CHARACTERISTICS; RISK STRATIFICATION; SERIAL MEASUREMENTS; CARDIAC BIOMARKERS; EUROPEAN-SOCIETY;

D O I：

10.1016/j.hfc.2017.08.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Galectin-3 plays a role in tissue inflammation, repair, and fibrosis. This article specifically focuses on heart failure (HF), in which galectin-3 has been shown to be a useful biomarker in prognosis and risk stratification, especially in HF with preserved ejection fraction. Experimental research has shown that galectin-3 directly induces pathologic remodeling of the heart, and is therefore considered a culprit protein in the development of cardiac fibrosis in HF, with potentially relevant clinical implications. In summary, galectin-3 is a biomarker and biotarget in cardiac remodeling and fibrosis and future research will target galectin-3-centered diseases.

引用

页码：75 / +

页数：19

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