TGF- signaling: A complex role in tumorigenesis

被引：126
作者：
Liu, Shuang [1 ]
Chen, Shuang [2 ]
Zeng, Jun [1 ]
机构：
[1] Chongqing Normal Univ, Dept Biochem & Mol Biol, Coll Life Sci, 37 Daxuecheng Middle Rd, Chongqing 401331, Peoples R China
[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing 400016, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2018年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
transforming growth factor-; epithelial-mesenchymal transition; cancer stem cells; inflammation; metastasis; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER METASTASIS; CELL-PROLIFERATION; HEPATOCELLULAR-CARCINOMA; TUMOR MICROENVIRONMENT; ANGIOGENESIS; MACROPHAGES; ACTIVATION; TGF-BETA-1;
D O I：
10.3892/mmr.2017.7970
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor- (TGF-) ligands (TGF-1, 2 and 3) are secreted inflammatory cytokines, which are known to be involved in various aspects of tumor development through two transmembrane serine-threonine kinase receptors, TGFR1 and TGFR2. TGF- promotes or inhibits tumorigenesis depending on the concurrent gene mutations and tissue microenvironment present through the small mothers against decapentaplegic (Smad) and non-Smad pathways. This review aims to provide a comprehensive overview of the role of the TGF- pathway in tumor initiation and progression.
引用
收藏
页码：699 / 704
页数：6
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