Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes

被引：64

作者：

Tong, Yiai ^{[1
]}

Merino, Diana ^{[5
]}

Nimmervoll, Birgit ^{[1
]}

Gupta, Kirti ^{[2
]}

Wang, Yong-Dong ^{[3
]}

Finkelstein, David ^{[3
]}

Dalton, James ^{[2
]}

Ellison, David W. ^{[2
]}

Ma, Xiaotu ^{[3
]}

Zhang, Jinghui ^{[3
]}

Malkin, David ^{[5
,6
]}

Gilbertson, Richard J. ^{[1
,4
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Computat Biol, Memphis, TN 38105 USA

[4] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[5] Univ Toronto, Hosp Sick Children, Dept Med Biophys, Genet & Genome Biol Program, Toronto, ON M5G 1X8, Canada

[6] Univ Toronto, Hosp Sick Children, Dept Med Biophys, Div Hematol Oncol, Toronto, ON M5G 1X8, Canada

来源：

CANCER CELL | 2015年 / 27卷 / 05期

关键词：

LI-FRAUMENI; TUMOR SUPPRESSORS; MUTATIONS; CANCER; MEDULLOBLASTOMA; P53; INHIBITION; COMPLEX; BINDING; ROLES;

D O I：

10.1016/j.ccell.2015.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Choroid plexus carcinomas (CPCs) are poorly understood and frequently lethal brain tumors with few treatment options. Using a mouse model of the disease and a large cohort of human CPCs, we performed a cross-species, genome-wide search for oncogenes within syntenic regions of chromosome gain. TAF12, NFYC, and RAD54L co-located on human chromosome 1p32-35.3 and mouse chromosome 4qD1-D3 were identified as oncogenes that are gained in tumors in both species and required for disease initiation and progression. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair. Our data identify a group of concurrently gained oncogenes that cooperate in the formation of CPC and reveal potential avenues for therapy.

引用

页码：712 / 727

页数：16

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