Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

被引：45

作者：

Alesci, Alessio ^{[1
]}

Lauriano, Eugenia Rita ^{[1
]}

Fumia, Angelo ^{[2
]}

Irrera, Natasha ^{[3
]}

Mastrantonio, Enza ^{[4
]}

Vaccaro, Mario ^{[5
]}

Gangemi, Sebastiano ^{[2
]}

Santini, Antonello ^{[6
]}

Cicero, Nicola ^{[7
]}

Pergolizzi, Simona ^{[1
]}

机构：

[1] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Stagno dAlcontres 31, I-98166 Messina, Italy

[2] Univ Messina, Dept Clin & Expt Med, Viale Gazzi, I-98147 Messina, Italy

[3] Univ Messina, Dept Clin & Expt Med, Sect Pharmacol, I-98125 Messina, Italy

[4] Azienda Sanit Prov Messina, I-98124 Messina, Italy

[5] Univ Messina, Dept Clin & Expt Med, Sect Dermatol, I-98125 Messina, Italy

[6] Univ Napoli Federico II, Dept Pharm, I-80131 Naples, Italy

[7] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, I-98125 Messina, Italy

来源：

MOLECULES | 2022年 / 27卷 / 06期

关键词：

psoriasis; immune system; immune cells; depression; stress; natural products; CD8(+) T-CELLS; PLASMACYTOID DENDRITIC CELLS; INNATE LYMPHOID-CELLS; TOLL-LIKE RECEPTORS; CITRUS-BERGAMIA RISSO; NITRIC-OXIDE SYNTHASE; NORMAL HUMAN SKIN; ATOPIC-DERMATITIS; MOUSE MODEL; TNF-ALPHA;

D O I：

10.3390/molecules27061953

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%-3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

引用

页数：21

共 223 条

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