Background Congenital long-QT syndrome represents the most common cardiac channelopathy and manifests as potentially lethal ventricular arrhythmias. Prevention strategies include beta-blockade pharmacotherapy, implantable cardioverter-defibrillators, and left cardiac sympathetic denervation, which can increase the threshold for ventricular fibrillation. Herein, we report our experience with video-assisted thoracoscopic left cardiac sympathetic denervation. Methods We performed a retrospective review of the electronic medical records of all patients with congenital long-QT syndrome who underwent video-assisted thoracoscopic left cardiac sympathetic denervation at our institution. Results From September 2009 to May 2016, 6 patients with a mean age of 30.5 years (range 20-47 years) underwent video-assisted thoracoscopic left cardiac sympathetic denervation for medically refractory long-QT syndrome. All patients had an uneventful recovery and were discharged 1-3 days after the operation. At a median follow-up of 14 months (range 12-60 months), 4 patients had no cardiac events while 2 experienced 1 episode of arrhythmic syncope and 1 episode of appropriate implantable cardioverter-defibrillator shock. Following surgery, the mean annual cardiac events in the study cohort decreased from 2.13 to 0.33 (p = 0.004) and the mean corrected QT interval reduced from 560 ms to 491 ms (p = 0.006). Conclusions Video-assisted thoracoscopic left cardiac sympathetic denervation is a safe and effective therapy in patients with congenital long-QT syndrome who continue to suffer from recurrent life-threatening arrhythmias or frequent implantable cardioverter-defibrillator discharges despite maximum tolerated doses of beta blockers.
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Antiel, Ryan M.
Bos, J. Martijn
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Dept Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Bos, J. Martijn
Joyce, Daniel D.
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h-index: 0
机构:
Mayo Clin, Mayo Med Sch, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Joyce, Daniel D.
Owen, Heidi J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Owen, Heidi J.
Roskos, Penny L.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Roskos, Penny L.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Dept Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
机构:
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Bos, J. Martijn
Bos, Katy M.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Bos, Katy M.
Johnson, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Johnson, Jonathan N.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Surg, Div Pediat Surg, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
机构:Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Collura, Christopher A.
Johnson, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Johnson, Jonathan N.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Surg, Div Pediat Surg, Rochester, MN 55905 USAMayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Anesthesiol & Intens Care Med, Div Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
机构:
Zhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhejiang Univ, Atrial Fibrillat Ctr, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Han, Jie
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Ackerman, Michael J.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA
Mayo Clin, Div Pediat Surg, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Moir, Christopher
Cai, Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Cai, Cheng
Xiao, Pei-Lin
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 2, Chongqing, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Xiao, Pei-Lin
Zhang, Pei
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Cardiol, Sch Med, Hangzhou, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhang, Pei
Briske, Kaylie A.
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h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Briske, Kaylie A.
Zheng, Liang-Rong
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhejiang Univ, Atrial Fibrillat Ctr, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zheng, Liang-Rong
Chen, Peng-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA
Indiana Univ, Div Cardiol, Dept Med, Sch Med, Indianapolis, IN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Chen, Peng-Sheng
Cha, Yong-Mei
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Antiel, Ryan M.
Bos, J. Martijn
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Dept Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Bos, J. Martijn
Joyce, Daniel D.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Mayo Med Sch, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Joyce, Daniel D.
Owen, Heidi J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Owen, Heidi J.
Roskos, Penny L.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Roskos, Penny L.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Dept Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Div Pediat Surg, Dept Gen Surg, Rochester, MN 55905 USA
机构:
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Bos, J. Martijn
Bos, Katy M.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Bos, Katy M.
Johnson, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Johnson, Jonathan N.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Surg, Div Pediat Surg, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
Mayo Clin, Dept Pediat & Adolescent Med, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Med, Div Cardiovasc Dis, Rochester, MN 55905 USAMayo Clin, Windland Smith Rice Sudden Death Genom Lab, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA
机构:Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Collura, Christopher A.
Johnson, Jonathan N.
论文数: 0引用数: 0
h-index: 0
机构:Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Johnson, Jonathan N.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Surg, Div Pediat Surg, Rochester, MN 55905 USAMayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Moir, Christopher
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
Mayo Clin, Dept Anesthesiol & Intens Care Med, Div Cardiovasc Dis, Rochester, MN 55905 USA
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USAMayo Clin, Long QT Syndrome Clin, Dept Pediat, Div Pediat Cardiol, Rochester, MN 55905 USA
机构:
Zhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhejiang Univ, Atrial Fibrillat Ctr, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Han, Jie
Ackerman, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA
Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Ackerman, Michael J.
Moir, Christopher
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USA
Mayo Clin, Div Pediat Surg, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Moir, Christopher
Cai, Cheng
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Cai, Cheng
Xiao, Pei-Lin
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Cardiovasc Med, Affiliated Hosp 2, Chongqing, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Xiao, Pei-Lin
Zhang, Pei
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Cardiol, Sch Med, Hangzhou, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhang, Pei
Briske, Kaylie A.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pediat & Adolescent Med, Rochester, MN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Briske, Kaylie A.
Zheng, Liang-Rong
论文数: 0引用数: 0
h-index: 0
机构:
Zhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zhejiang Univ, Atrial Fibrillat Ctr, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Zheng, Liang-Rong
Chen, Peng-Sheng
论文数: 0引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Krannert Inst Cardiol, Indianapolis, IN 46202 USA
Indiana Univ, Div Cardiol, Dept Med, Sch Med, Indianapolis, IN USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
Chen, Peng-Sheng
Cha, Yong-Mei
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USAZhejiang Univ, Dept Cardiol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China