Increased levels of proteins of the acute inflammatory phase in the peritoneal fluid of women with advanced stages of endometriosis

被引:0
作者
Polak, Grzegorz [1 ]
Barczynski, Bartlomiej [1 ]
Bednarek, Wieslawa [1 ]
Kwasniewski, Wojciech [1 ]
Wertel, Iwona [1 ]
Derewianka-Polak, Magdalena [2 ]
Makara-Studzinska, Marta [2 ]
Kotarski, Jan [1 ]
机构
[1] Med Univ Lublin, Dept Oncol Gynecol & Gynecol 1, PL-20081 Lublin, Poland
[2] Med Univ Lublin, Dept Appl Psychol, PL-20081 Lublin, Poland
关键词
acute inflammatory phase proteins; endometriosis; haptoglobin; ceruloplasmin; HAPTOGLOBIN; CERULOPLASMIN; EXPRESSION; CYTOKINES; PLASMA;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objectives: Most investigators agree that endometriosis is associated with a state of subclinical, non-infectious peritoneal inflammation. The objective of the study was to assess concentrations of two markers of the acute inflammatory phase proteins, haptoglobin and ceruloplasmin, in peritoneal fluid of endometriotic women. Material and methods: 229 women who underwent diagnostic or therapeutic laparoscopy were included in the study Minimal, mild, moderate and severe endometriosis according to ASRM was confirmed in 119 women (study groups), whereas 110 patients suffered from simple serous or dermoid ovarian cysts (reference groups). Haptoglobin and ceruloplasmin concentrations in the peritoneal fluid samples aspirated during laparoscopy were measured using commercially available radial immunodiffusion kits. Results: The concentration of haptoglobin in the peritoneal fluid of women with endometriosis was significantly higher as compared to patients with serous and dermoid ovarian cysts. Significantly higher haptoglobin level was observed in patients with severe and moderate endometriosis as compared to women from both reference groups. No significant difference in the peritoneal fluid ceruloplasmin levels was found between patients with endometriosis and women from reference groups. However, it was noted that ceruloplasmin levels are higher in the subgroup of patients with severe endometriosis as compared to both reference groups and women with mild disease. Conclusions: Our results support the hypothesis that endometriosis is associated with subclinical inflammation within the peritoneal cavity It may be speculated that pro-inflammatory stimuli strong enough to cause an increase in acute inflammatory phase proteins peritoneal fluid concentrations are observed only in the advanced stages of the disease.
引用
收藏
页码:414 / 418
页数:5
相关论文
共 22 条
[1]   Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release [J].
Arredouani, M ;
Matthijs, P ;
Van Hoeyveld, E ;
Kasran, A ;
Baumann, H ;
Ceuppens, JL ;
Stevens, E .
IMMUNOLOGY, 2003, 108 (02) :144-151
[2]  
Canis M, 1997, FERTIL STERIL, V67, P817
[3]   Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases [J].
Carter, Kymberley ;
Worwood, Mark .
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2007, 29 (02) :92-110
[4]   IDENTIFICATION OF HAPTOGLOBIN AS AN ANGIOGENIC FACTOR IN SERA FROM PATIENTS WITH SYSTEMIC VASCULITIS [J].
CID, MC ;
GRANT, DS ;
HOFFMAN, GS ;
AUERBACH, R ;
FAUCI, AS ;
KLEINMAN, HK .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (03) :977-985
[5]  
Dumoulin MJ, 1996, ARZNEIMITTELFORSCH, V46, P855
[6]  
DUNSELMAN GAJ, 1988, J REPROD FERTIL, V83, P803
[7]   Haptoglobin β chain isoforms in the plasma and peritoneal fluid of women with endometriosis [J].
Ferrero, S ;
Gillott, DJ ;
Remorgida, V ;
Anserini, P ;
Price, K ;
Ragni, N ;
Grudzinskas, JG .
FERTILITY AND STERILITY, 2005, 83 (05) :1536-1543
[8]   Peritoneal fluid proteome in women with different ASRM stages of endometriosis [J].
Ferrero, Simone ;
Gillott, David J. ;
Remorgida, Valentino ;
Anserini, Paola ;
Ragni, Nicola ;
Grudzinskas, Jurgis G. .
GYNECOLOGICAL ENDOCRINOLOGY, 2008, 24 (08) :433-441
[9]   Mechanisms of disease: Acute-phase proteins and other systemic responses to inflammation [J].
Gabay, C ;
Kushner, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (06) :448-454
[10]   Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis [J].
Gazvani, R ;
Templeton, A .
REPRODUCTION, 2002, 123 (02) :217-226