Death in the fast lane: what's next for necroptosis?

被引：32

作者：

Oberst, Andrew ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

FEBS JOURNAL | 2016年 / 283卷 / 14期

关键词：

apoptosis; caspase-8; MLKL; necroptosis; RIPK1; RIPK3; HOMOTYPIC INTERACTION MOTIF; MIXED LINEAGE KINASE; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; TNF-INDUCED NECROPTOSIS; CELL-DEATH; PROGRAMMED NECROSIS; INDUCED CYTOKINE; RIP KINASES; PROTEIN;

D O I：

10.1111/febs.13520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Necroptosis is a form of programmed cell death that is both mechanistically and morphologically distinct from apoptosis, the canonical mechanism of cell suicide. Although early descriptions of necroptosis date back decades, the last 5 years have seen a proliferation of studies of this process. This surge in interest has included the recent publication of several excellent, in-depth reviews of the literature [Chan FK-M et al. (2014) Annu Rev Immunol 33, 141210135520002; Weinlich R & Green DR (2014) Mol Cell 56, 469-480; Silke J et al. (2015) Nat Immunol 16, 689-697; Linkermann A & Green DR (2014) N Engl J Med 370, 455-465]. Rather than contribute another summary to this well-summarized field, in this Minireview I will briefly discuss key recent findings, then touch on some of the major outstanding questions -the known unknowns - that remain.

引用

页码：2616 / 2625

页数：10

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