Death in the fast lane: what's next for necroptosis?

被引：32

作者：

Oberst, Andrew ^{[1
]}

机构：

[1] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

FEBS JOURNAL | 2016年 / 283卷 / 14期

关键词：

apoptosis; caspase-8; MLKL; necroptosis; RIPK1; RIPK3; HOMOTYPIC INTERACTION MOTIF; MIXED LINEAGE KINASE; NF-KAPPA-B; NLRP3 INFLAMMASOME ACTIVATION; TNF-INDUCED NECROPTOSIS; CELL-DEATH; PROGRAMMED NECROSIS; INDUCED CYTOKINE; RIP KINASES; PROTEIN;

D O I：

10.1111/febs.13520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Necroptosis is a form of programmed cell death that is both mechanistically and morphologically distinct from apoptosis, the canonical mechanism of cell suicide. Although early descriptions of necroptosis date back decades, the last 5 years have seen a proliferation of studies of this process. This surge in interest has included the recent publication of several excellent, in-depth reviews of the literature [Chan FK-M et al. (2014) Annu Rev Immunol 33, 141210135520002; Weinlich R & Green DR (2014) Mol Cell 56, 469-480; Silke J et al. (2015) Nat Immunol 16, 689-697; Linkermann A & Green DR (2014) N Engl J Med 370, 455-465]. Rather than contribute another summary to this well-summarized field, in this Minireview I will briefly discuss key recent findings, then touch on some of the major outstanding questions -the known unknowns - that remain.

引用

页码：2616 / 2625

页数：10

共 66 条

[1] Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice [J].

Berger, Scott B. ;

Kasparcova, Viera ;

Hoffman, Sandy ;

Swift, Barb ;

Dare, Lauren ;

Schaeffer, Michelle ;

Capriotti, Carol ;

Cook, Michael ;

Finger, Joshua ;

Hughes-Earle, Angela ;

Harris, Philip A. ;

Kaiser, William J. ;

Mocarski, Edward S. ;

Bertin, John ;

Gough, Peter J. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (12) :5476-5480

[2] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [J].

Cai, Zhenyu ;

Jitkaew, Siriporn ;

Zhao, Jie ;

Chiang, Hsueh-Cheng ;

Choksi, Swati ;

Liu, Jie ;

Ward, Yvona ;

Wu, Ling-gang ;

Liu, Zheng-Gang .

NATURE CELL BIOLOGY, 2014, 16 (01) :55-+

[3]

Chan FK-M, 2014, ANNU REV IMMUNOL, V33

[4] Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 [J].

Chen, Wanze ;

Wu, Jianfeng ;

Li, Lisheng ;

Zhang, Zhengmao ;

Ren, Junming ;

Liang, Yaoji ;

Chen, Fenfang ;

Yang, Chao ;

Zhou, Zhenru ;

Su, Sheng Sean ;

Zheng, Xinru ;

Zhang, Zhirong ;

Zhong, Chuan-Qi ;

Wan, Haoqiang ;

Xiao, Mu ;

Lin, Xia ;

Feng, Xin-Hua ;

Han, Jiahuai .

NATURE CELL BIOLOGY, 2015, 17 (04) :434-+

[5] Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling [J].

Chen, Wanze ;

Zhou, Zhenru ;

Li, Lisheng ;

Zhong, Chuan-Qi ;

Zheng, Xinru ;

Wu, Xiurong ;

Zhang, Yingying ;

Ma, Huan ;

Huang, Deli ;

Li, Wenjuan ;

Xia, Zongping ;

Han, Jiahuai .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (23) :16247-16261

[6] Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation [J].

Cho, YoungSik ;

Challa, Sreerupa ;

Moquin, David ;

Genga, Ryan ;

Ray, Tathagat Dutta ;

Guildford, Melissa ;

Chan, Francis Ka-Ming .

CELL, 2009, 137 (06) :1112-1123

[7] Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination [J].

de Almagro, M. C. ;

Goncharov, T. ;

Newton, K. ;

Vucic, D. .

CELL DEATH & DISEASE, 2015, 6 :e1800-e1800

[8] Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury [J].

Degterev A. ;

Huang Z. ;

Boyce M. ;

Li Y. ;

Jagtap P. ;

Mizushima N. ;

Cuny G.D. ;

Mitchison T.J. ;

Moskowitz M.A. ;

Yuan J. .

Nature Chemical Biology, 2005, 1 (2) :112-119

[9] RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3 [J].

Dillon, Christopher P. ;

Weinlich, Ricardo ;

Rodriguez, Diego A. ;

Cripps, James G. ;

Quarato, Giovanni ;

Gurung, Prajwal ;

Verbist, Katherine C. ;

Brewer, Taylor L. ;

Llambi, Fabien ;

Gong, Yi-Nan ;

Janke, Laura J. ;

Kelliher, Michelle A. ;

Kanneganti, Thirumala-Devi ;

Green, Douglas R. .

CELL, 2014, 157 (05) :1189-1202

[10] MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates [J].

Dondelinger, Yves ;

Declercq, Wim ;

Montessuit, Sylvie ;

Roelandt, Ria ;

Goncalves, Amanda ;

Bruggeman, Inge ;

Hulpiau, Paco ;

Weber, Kathrin ;

Sehon, Clark A. ;

Marquis, Robert W. ;

Bertin, John ;

Gough, Peter J. ;

Savvides, Savvas ;

Martinou, Jean-Claude ;

Bertrand, Mathieu J. M. ;

Vandenabeele, Peter .

CELL REPORTS, 2014, 7 (04) :971-981

← 1 2 3 4 5 6 7 →