Immune cell-derived small extracellular vesicles in cancer treatment

被引：25

作者：

Choi, Sung-Jin ^{[1
]}

Cho, Hanchae ^{[2
]}

Yea, Kyungmoo ^{[1
]}

Baek, Moon-Chang ^{[2
]}

机构：

[1] DGIST, Dept New Biol, Daegu 42988, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Mol Med, Exosome Convergence Res Ctr ECRC,CMRI, Daegu 41944, South Korea

来源：

BMB REPORTS | 2022年 / 55卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Cancer-immune cycle; Cancer immunotherapy; Exosomes; Immune cells; Small extracellular vesicles; NATURAL-KILLER-CELLS; MATURE DENDRITIC CELLS; T-CELLS; TUMOR MICROENVIRONMENT; IN-VITRO; EXOSOMES; ACTIVATE; VACCINE; METASTASIS; BIOGENESIS;

D O I：

10.5483/BMBRep.2022.55.1.133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small extracellular vesicles (sEVs) secreted by most cells carry bioactive macromolecules including proteins, lipids, and nucleic acids for intercellular communication. Given that some immune cell-derived sEVs exhibit anti-cancer properties, these sEVs have received scientific attention for the development of novel anticancer immunotherapeutic agents. In this paper, we reviewed the latest advances concerning the biological roles of immune cell-derived sEVs for cancer therapy. sEVs derived from immune cells including dendritic cells (DCs), T cells, natural-killer (NK) cells, and macrophages are good candidates for sEV-based cancer therapy. Besides their role of cancer vaccines, DC-shed sEVs activated cytotoxic lymphocytes and killed tumor cells. sEVs isolated from NK cells and chimeric antigen receptor (CAR) T cells exhibited cytotoxicity against cancer cells. sEVs derived from CD8(+) T and CD4(+) T cells inhibited cancer-associated cells in tumor microenvironment (TME) and activated B cells, respectively. M1-macrophage-derived sEVs induced M2 to M1 repolarization and also created a pro-inflammatory environment. Hence, these sEVs, via mono or combination therapy, could be considered in the treatment of cancer patients in the future. In addition, sEVs derived from cytokine-stimulated immune cells or sEV engineering could improve their anti-tumor potency.

引用

页码：48 / 56

页数：9