Genetic polymorphisms and multiple myeloma risk: a meta-analysis

被引：2
作者：
Zhang, Pengcheng [1 ,2 ,3 ]
Liu, Bing [2 ,3 ]
机构：
[1] Acad Mil Sci, Acad Mil Med Sci, Inst Environm & Operat Med, Tianjin 300041, Peoples R China
[2] Acad Mil Sci, Acad Mil Med Sci, State Key Lab Pmte, Beijing 100071, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, State Key Lab Expt Hematol, Beijing 100071, Peoples R China
来源：
ANNALS OF HEMATOLOGY | 2020年 / 99卷 / 05期
关键词：
Interleukin-6; Multidrug resistance 1; Multiple myeloma; Methylenetetrahydrofolate reductase; Tumor necrosis factor-alpha; NECROSIS-FACTOR-ALPHA; METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR; MULTIDRUG-RESISTANCE; PROMOTER; CANCER; INTERLEUKIN-6; ASSOCIATION; GROWTH; MDR1; OVEREXPRESSION;
D O I：
10.1007/s00277-020-03979-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous researches exploring associations between multiple myeloma (MM) and genetic polymorphisms showed controversial results. In this investigation, we aimed to make a meta-analysis to assess the association between MM risk and genetic polymorphisms. We searched for articles on genetic polymorphism and MM risk in Web of Science and PubMed databases from 1951 to August 2019. We computed the odds ratio (OR) and 95% confidence intervals (CI) extracted from included articles. The meta-analysis showed no significant associations between MM risks and tumor necrosis factor (TNF)-alpha (rs1800629/rs361525/rs1799724), interleukin (IL)-6 (rs1800795), multidrug resistance 1 (MDR1) (rs1045642), Methylenetetrahydrofolate reductase (MTHFR) (rs1801131/rs1801133) polymorphisms. In summary, the study shows that the TNF-alpha (rs1800629/rs361525/rs1799724), IL-6 (rs1800795), MDR1 (rs1045642), and MTHFR (rs1801131/rs1801133) polymorphisms may not be associated with MM susceptibility. Thus, we do not need more expensive and useless studies to explore the associations between MM risks and these genetic polymorphisms.
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页码：1017 / 1024
页数：8
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